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Cases of Pernio-Like Lesions after mRNA-1273 Vaccination with Clinical and Pathological Features: A Single-Center

Young-Wook Ryoo1, Ji-Min Yun1, Hyun-Wook Kim1

  • 1Department of Dermatology, Keimyung University School of Medicine, Daegu, Korea.

Annals of Dermatology
|December 7, 2023
PubMed

Insights

Pernio-like lesions, a skin condition, can occur after COVID-19 vaccination, particularly with mRNA vaccines. This study highlights four cases, suggesting this side effect may be more common than previously thought.

Area of Science:

  • Dermatology
  • Vaccinology
  • Immunology

Background:

  • South Korea offers mRNA (Moderna, Pfizer) and adenoviral vector (AstraZeneca, Janssen) COVID-19 vaccines.
  • Dermatologic side effects are known, ranging from injection site reactions to systemic rashes.
  • Pernio-like lesions, common in COVID-19, are rarely reported post-vaccination.

Observation:

  • Four cases of pernio-like lesions were observed within two months at a single tertiary hospital.
  • All cases occurred after the first dose of the mRNA-1273 (Moderna) vaccine.
  • The study details the clinical and pathological characteristics of these cases.

Findings:

  • Pernio-like lesions are a potential, albeit rare, cutaneous side effect of COVID-19 vaccination.
  • Comparison with existing literature suggests an underreporting of this specific side effect.
  • The observed cases provide further evidence linking mRNA vaccination to pernio-like reactions.

Implications:

  • Clinicians should be aware of pernio-like lesions as a possible adverse reaction to COVID-19 vaccines.
  • Increased recognition may lead to better patient management and understanding of vaccine-induced immune responses.
  • Real-world data suggests the incidence of this side effect might be higher than currently documented.
Keywords:
Adverse drug reactionsCOVID-19ChilblainsmRNA-1273

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