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Thermoring basis for the TRPV3 bio-thermometer
Guangyu Wang1,2
1Department of Physiology and Membrane Biology, University of California School of Medicine, Davis, CA, 95616, USA. gary.wang10@gmail.com.
Scientific Reports
|December 7, 2023
Summary
Graph theory reveals how structural grids in thermosensitive TRP channels, like TRPV3, dictate temperature sensitivity. These interconnected grids control gating thresholds and heat efficacy, providing a thermodynamic model for these bio-thermometers.
Area of Science:
- Biophysics
- Structural Biology
- Computational Biology
Background:
- Thermosensitive transient receptor potential (TRP) channels function as biological thermometers.
- Their precise structural basis for temperature sensitivity and gating remains largely unknown.
Purpose of the Study:
- To investigate the structural origins of temperature thresholds and sensitivity in thermosensitive TRP channels.
- To develop a graph theory-based thermodynamic model for thermo-gated TRPV3 channels.
Main Methods:
- Applied graph theory to analyze non-covalent interactions in 3D structures of TRPV3.
- Modeled temperature-dependent interactions as a fluidic grid-like mesh network of 'thermo-rings'.
Main Results:
- Identified a hierarchical grid network within TRPV3 structures, ranging from largest to smallest grids.
- Heat-evoked melting of larger grids correlates with initiating channel gating thresholds.
- Smaller grids appear essential for maintaining heat efficacy, and all grids contribute to molar heat capacity for temperature sensitivity.
Conclusions:
- A graph theory-based thermodynamic model elucidates the structural basis of thermo-gated TRP channels.
- The grid network model explains variable temperature thresholds and sensitivity in these bio-thermometers.
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