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Luteibacter jiangsuensis blood stream infection: a first case report.
Takanori Horiguchi1, Makoto Sumiyoshi1, Eri Nagatomo2
1Division of Respirology, Rheumatology, Infectious Diseases, and Neurology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
BMC Infectious Diseases
|December 7, 2023
Summary
The first human infection caused by Luteibacter jiangsuensis, a gram-negative bacillus, was reported in a Crohn's disease patient. This bacterium, identified via 16S rRNA gene sequencing, showed carbapenem resistance.
Area of Science:
- Medical microbiology
- Infectious diseases
- Bacteriology
Background:
- Luteibacter jiangsuensis, a gram-negative aerobic bacillus, was first isolated from soil in China in 2011.
- This report details the first documented human infection attributed to L. jiangsuensis.
Observation:
- A 59-year-old woman with Crohn's disease presented with fever and catheter-related bloodstream infection.
- Blood and catheter-tip cultures revealed glucose non-fermentative gram-negative bacilli.
- Initial identification by MALDI-TOF mass spectrometry was unsuccessful; 16S rRNA gene sequencing confirmed L. jiangsuensis.
Findings:
- The identified L. jiangsuensis isolate exhibited resistance to carbapenems.
- The patient was successfully treated with intravenous levofloxacin after meropenem was discontinued.
- The patient recovered and was discharged after 14 days of levofloxacin therapy.
Implications:
- This case highlights L. jiangsuensis as a potential human pathogen.
- Accurate identification using 16S rRNA gene sequencing is crucial for this bacterium.
- Understanding antimicrobial resistance patterns, such as carbapenem resistance, is vital for effective treatment strategies.
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