Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health
Inés Domínguez-López1,2,3, Polina Galkina1, Isabella Parilli-Moser1,2,3
1Polyphenol Research Group, Department of Nutrition, Food Science and Gastronomy, School of Pharmacy and Food Sciences, Barcelona, Catalunya, Spain.
Molecular Nutrition & Food Research
|December 8, 2023
Summary
The Mediterranean diet is linked to specific microbial phenolic metabolites (MPM) in urine, which are associated with better cognitive function in older adults at high cardiovascular risk.
Area of Science:
- Nutrition Science
- Microbiome Research
- Cognitive Aging
Background:
- Polyphenol-rich diets are linked to improved cognitive performance.
- Understanding the role of gut microbiota in mediating diet-cognition relationships is crucial.
Purpose of the Study:
- To investigate the association between urinary microbial phenolic metabolites (MPM) and cognitive function.
- To explore these relationships in an older population at high cardiovascular risk.
Main Methods:
- Cross-sectional analysis of 400 participants from the PREDIMED-Plus study.
- Liquid chromatography-mass spectrometry for urinary MPM identification.
- Mediterranean diet adherence and cognitive function assessed via questionnaires and neuropsychological tests.
Main Results:
- Specific MPMs, like protocatechuic acid and enterolactone glucuronide, correlated with higher Mediterranean diet adherence.
- Several MPMs, including protocatechuic acid and enterodiol glucuronide, were directly associated with global cognitive scores.
- Certain MPMs showed associations with specific cognitive tests like the Mini-Mental State Examination and Clock Drawing Test.
Conclusions:
- The Mediterranean diet influences urinary MPM profiles.
- These MPMs are associated with enhanced cognitive performance in older adults.
- This highlights a potential mechanism linking diet, gut microbiota, and brain health.
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