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Bioprinting Using Organ Building Blocks: Spheroids, Organoids, and Assembloids
Leandra Santos Baptista1,2,3, Vladimir Mironov1, Elizaveta Koudan4
1Campus Duque de Caxias Prof Geraldo Cidade, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Tissue Engineering. Part A
|December 8, 2023
Summary
Scaffold-free 3D bioprinting utilizes organ building blocks (OBB) for creating tissue constructs. This approach offers a promising alternative to traditional methods in regenerative medicine.
Area of Science:
- Biotechnology
- Regenerative Medicine
- Tissue Engineering
Background:
- Three-dimensional (3D) bioprinting is an advanced tissue engineering technique using biomaterials and living cells to create functional tissue constructs.
- Traditional methods rely on scaffolds, but scaffold-free approaches are emerging, utilizing self-assembling organ building blocks (OBB).
Purpose of the Study:
- To explore the diverse range of organ building blocks (OBB) used in scaffold-free 3D bioprinting.
- To present the evolving bioprinting and bioassembly techniques involving OBB.
- To outline the benefits, challenges, and future outlook of OBB in organ printing.
Main Methods:
- Review of organ building blocks (OBB) including spheroids, organoids, and assembloids.
- Discussion of various scaffold-free bioprinting and bioassembly methodologies.
- Analysis of advantages, limitations, and future prospects.
Main Results:
- Organ building blocks (OBB) are increasingly employed in scaffold-free 3D bioprinting.
- A growing array of bioprinting and bioassembly techniques are being developed for OBB utilization.
- Scaffold-free bioprinting with OBB presents unique advantages and challenges for organ printing.
Conclusions:
- Scaffold-free 3D bioprinting with OBB represents a significant advancement in tissue engineering.
- Further research into OBB and associated technologies is crucial for realizing the potential of organ printing.
- This approach holds promise for future regenerative medicine applications.
