Open Questions of Chemically Powered Nano- and Micromotors

Chemically powered nano- and micromotors are microscopic devices that convert chemical energy into motion. Interest in these motors has grown over the past 20 years because they exhibit interesting collective behaviors and have found potential uses in biomedical and environmental applications. Understanding how these motors operate both individually and collectively and how environments affect their operation is of both fundamental and applied significance. However, there are still significant gaps in our knowledge. This Perspective highlights several open questions regarding the propulsion mechanisms of, interactions among, and impact of confinements on nano- and micromotors driven by self-generated chemical gradients. These questions are based on my own experience as an experimentalist. For each open question, I describe the problem and its significance, analyze the status-quo, identify the bottleneck problem, and propose potential solutions. An underlying theme for these questions is the interplay among reaction kinetics, physicochemical distributions, and fluid flows. Unraveling this interplay requires careful measurements as well as a close collaboration between experimentalists and theoreticians/numerical experts. The interdisciplinary nature of these challenges suggests that their solutions could bring new revelations and opportunities across disciplines such as colloidal sciences, material sciences, soft matter physics, robotics, and beyond.