Can antimicrobial blue light contribute to resistance development? Genome-wide analysis revealed aBL-protective genes
Beata Kruszewska-Naczk1,2, Mariusz Grinholc1, Krzysztof Waleron2
1Laboratory of Photobiology and Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk , Gdansk, Poland.
Importance:
Increasing antibiotic resistance and the lack of new antibiotic-like compounds to combat bacterial resistance are significant problems of modern medicine. The development of new alternative therapeutic strategies is extremely important. Antimicrobial blue light (aBL) is an innovative approach to combat multidrug-resistant microorganisms. aBL has a multitarget mode of action; however, the full mechanism of aBL antibacterial action requires further investigation. In addition, the potential risk of resistance development to this treatment should be considered.
