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Cefepime-induced Acute Liver Injury in a 5-Year-old Boy

Lael Mode1, Judith A Guzman-Cottrill1,2, Mikelle Bassett1,2

  • 1From the School of Medicine.

The Pediatric Infectious Disease Journal
|December 8, 2023
PubMed

Insights

A rare case of cefepime-induced acute liver injury in a child is presented. The liver injury resolved after discontinuing the antibiotic, highlighting a potential adverse effect of cefepime in pediatric patients.

Area of Science:

  • Pediatric infectious diseases
  • Hepatology
  • Clinical pharmacology

Background:

  • Cephalosporins are common antibiotics for pediatric infections.
  • Cefepime, a fourth-generation cephalosporin, is generally safe in children.
  • Acute liver injury is a rare but serious adverse drug reaction.

Observation:

  • A pediatric patient developed acute liver injury.
  • The patient was treated with cefepime for an infection.
  • Cefepime was identified as the likely cause of the liver injury.

Findings:

  • Cefepime-induced acute liver injury is a rare adverse event.
  • Liver function normalized after cefepime discontinuation.
  • This case highlights the importance of monitoring liver function in pediatric patients receiving cefepime.

Implications:

  • Clinicians should be aware of the potential for cefepime-induced liver injury in children.
  • Prompt recognition and discontinuation of cefepime can lead to recovery.
  • Further research may be needed to understand the mechanisms of cefepime hepatotoxicity.

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