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Association between the cardiometabolic index and chronic kidney disease: a cross-sectional study

Qian Guo1, Yani Wang1, Yuchen Liu1

  • 1Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China.

International Urology and Nephrology
|December 8, 2023
PubMed

Insights

Higher cardiometabolic index (CMI), an indicator of central obesity, is linked to increased chronic kidney disease (CKD) risk in the general American population. This study found a significant association between elevated CMI levels and a greater likelihood of developing CKD.

Area of Science:

  • Cardiology
  • Nephrology
  • Public Health

Background:

  • Central obesity is a known risk factor for chronic kidney disease (CKD).
  • The specific relationship between the cardiometabolic index (CMI) and CKD prevalence requires further investigation.
  • Understanding this association is crucial for public health strategies targeting metabolic syndrome and kidney health.

Purpose of the Study:

  • To investigate the correlation between the cardiometabolic index (CMI) and the risk of chronic kidney disease (CKD).
  • To assess the association in a large, representative sample of the general American population.
  • To determine if higher CMI levels are independently associated with increased CKD risk.

Main Methods:

  • A cross-sectional study utilizing data from 64,313 participants aged 20 years and older from the National Health and Nutrition Examination Survey (NHANES) (1999-2020).
  • Participants were categorized into three groups based on CMI tertiles (T1, T2, T3).
  • Logistic regression analysis, incorporating NHANES-recommended weights, was employed to evaluate the association between CMI and CKD.

Main Results:

  • The overall prevalence of CKD among the 21,765 included participants was 12.2%.
  • CKD prevalence increased significantly with rising CMI tertiles, from 8.9% in T1 to 16.0% in T3 (P < 0.001).
  • After adjusting for confounders, higher CMI tertiles demonstrated a significantly higher risk of CKD (T3 vs. T1: OR 1.22, 95% CI 1.05-1.43, P=0.013).

Conclusions:

  • Elevated cardiometabolic index (CMI) is independently associated with an increased risk of chronic kidney disease (CKD).
  • These findings highlight the importance of monitoring CMI as a potential indicator for CKD risk in the general population.
  • Public health initiatives may benefit from incorporating CMI assessment in strategies for preventing and managing kidney disease.
Abstract

Keywords:
Cardiometabolic indexCentral obesityChronic kidney diseaseNHANES

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