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Comparison of Protocol-Based Continuous and Intermittent Tube Feeding in Mechanically Ventilated Critically Ill
Vijaya Kumar1, Jhuma Sankar1, Manisha Jana2
1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110029, India.
Insights
Continuous tube feeding (CTF) and intermittent tube feeding (ITF) showed no significant difference in the time critically ill children reached target calories and protein. Both enteral nutrition methods are equally effective for nutritional support.
Area of Science:
- Pediatric critical care medicine
- Clinical nutrition
- Gastroenterology
Background:
- Optimizing nutritional delivery is crucial for critically ill children.
- Enteral nutrition is preferred, but delivery methods vary.
- Continuous tube feeding (CTF) and intermittent tube feeding (ITF) are common methods.
Purpose of the Study:
- To compare the efficacy of CTF versus ITF in critically ill children.
- To determine the time to reach target calorie and protein intake.
- To evaluate secondary outcomes including feed intolerance and mortality.
Main Methods:
- Randomized trial in a Pediatric Intensive Care Unit (PICU).
- Children randomized to CTF or ITF groups.
- Primary outcome: time to reach 70% WHO target calories and 1.5 g/kg ASPEN target protein.
Main Results:
- No significant difference in time to reach target calories (p=0.69) or protein (p=0.55) between CTF and ITF.
- Median times for target calories: 1.7 days (CTF) vs. 1.8 days (ITF).
- Other outcomes, including mortality and feed intolerance, were not significantly different.
Conclusions:
- CTF and ITF demonstrate comparable effectiveness in achieving nutritional targets in critically ill children.
- The choice of feeding method may not impact the speed of nutritional delivery.
- Further research could explore patient-centered outcomes.
Objectives:
To compare the time taken to reach the target calories and proteins by protocol based "continuous tube feeding (CTF)" and "intermittent tube feeding (ITF)" in critically ill children.
Methods:
This trial was conducted in the Pediatric Intensive Care Unit (PICU) of a tertiary care institute. Eligible children were randomized to receive CTF or ITF. Target calories were defined as 70% of calorie amount as per the WHO formula and target protein was defined as 1.5 g/kg as per the American Society of Parenteral and Enteral Nutrition (ASPEN) criteria. The primary outcome was time taken to reach target calories, the secondary outcomes were time taken to reach target protein, incidence of feed intolerance, PICU mortality, duration of ventilation, and outcome on 28th day.
Results:
Fifty-eight children were randomized; 29 in each group. The baseline characters were comparable. The median (IQR) times for reaching target calories were 1.7 (1.4, 2.5) d and 1.8 (1.4, 4.4) d in the CTF and ITF groups, respectively [Hazards ratio (HR) 0.89 (95% CI 0.5, 1.5); p = 0.69]. For the target protein intake, the median times were comparable in the 2 groups [HR 0.82 (95% CI 0.4-1.5); p = 0.55]. The other outcomes were not significantly different between the groups.
Conclusions:
The authors did not observe any difference in the time taken to reach target calories and protein between the two different modes of delivery of enteral nutrition.
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