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Related Concept Videos

Trachea01:22

Trachea

2.1K
The trachea, commonly known as the windpipe, is a vital part of the human respiratory system. It serves as a passageway for air to travel between the larynx and the bronchi, allowing oxygen to reach the lungs. Let's explore its anatomical features, dimensions, layers of the tracheal wall, associated muscles, and the functions of its parts.
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of...
2.1K
Tracheostomy: Procedure and Tubes01:28

Tracheostomy: Procedure and Tubes

620
A tracheostomy is a surgical procedure that creates an artificial opening into the trachea, typically at the second or third cartilaginous ring level. This opening allows the insertion of a tracheostomy tube, which can replace an endotracheal tube, provide mechanical ventilation, bypass an upper airway obstruction, or remove accumulated tracheobronchial secretions.
Tracheostomy tubes can be made of semiflexible plastic (polyurethane or silicone), rigid plastic, or metal, and they come in...
620
Oxygen Delivering System III: Tracheostomy and T-piece01:23

Oxygen Delivering System III: Tracheostomy and T-piece

1.0K
Oxygen delivery is critical in clinical care, especially for patients with respiratory disorders or those undergoing surgical procedures. Various systems, such as tracheostomy and the T-piece, deliver oxygen to the lungs, ensuring adequate arterial oxygenation.
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
1.0K
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

614
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
614
Tracheostomy Decannulation01:21

Tracheostomy Decannulation

185
Tracheostomy decannulation is a significant milestone in the liberation of mechanically ventilated patients. Despite its importance, there is no universally accepted protocol for this procedure. This demands an evidence-based, individualized approach.
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
185
Tracheostomy Care I: Pre-procedural Steps01:16

Tracheostomy Care I: Pre-procedural Steps

196
A tracheostomy is a surgical technique that involves making an incision in the neck to provide access to the trachea. It is frequently used in medical conditions such as airway obstruction and prolonged mechanical ventilation. Effective nursing management is crucial for the long-term success of a tracheostomy.
Required Equipment
The equipment necessary for tracheostomy care includes:
196

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Related Experiment Video

Updated: Jul 9, 2025

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
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Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model

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Breathing room: Toward next-generation tracheal engineering.

Alexandra A Dumas1, Ryan M Friedman1, Kyra W Y Smith1

  • 1Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Surgery, Division of Otolaryngology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Cell Stem Cell
|December 8, 2023
PubMed
Summary

Engineered trachea development is challenging. A novel stacked ring approach successfully maintained rabbit trachea patency for 8 weeks, offering a promising solution for tracheal regeneration.

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Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue
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Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease
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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Creating functional engineered tracheas with adequate mechanical strength and cellular characteristics for clinical use is a significant hurdle.
  • Existing methods struggle to replicate the complex structure and mechanical integrity of native tracheal tissue.

Purpose of the Study:

  • To develop and evaluate a novel stacked biomaterial approach for engineering tracheal segments.
  • To assess the integration, patency, and mechanical stability of the engineered trachea in a preclinical model.

Main Methods:

  • A stacked construction method was employed, alternating between cartilaginous and fibrous ring materials.
  • The engineered tracheal segment was surgically implanted into rabbits.
  • Assessment of integration, patency, and tissue response was performed over an 8-week period.

Main Results:

  • The engineered tracheal segment demonstrated successful integration within the host tissue.
  • Tracheal patency was maintained throughout the 8-week observation period.
  • The stacked ring design provided structural support and promoted tissue retention.

Conclusions:

  • The proposed stacked approach of alternating cartilaginous and fibrous rings is a viable strategy for engineering tracheal segments.
  • This method shows promise for generating functional tracheal replacements with sustained patency in vivo.
  • Further research can explore long-term outcomes and scalability for clinical translation.