Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Specific gut microbiome and metabolome changes in patients with continuous ambulatory peritoneal dialysis and comparison between patients with different dialysis vintages.

Frontiers in medicine·2024
Same author

Acta pharmaceutica Sinica. B·2024
Same author

Assessing psychometric properties and measurement invariance of the Sleep Quality Questionnaire among healthcare students.

BMC psychology·2024
Same author

Sema3A secreted by sensory nerve induces bone formation under mechanical loads.

International journal of oral science·2024
Same author

Sleep quality and subjective well-being in healthcare students: examining the role of anxiety and depression.

Frontiers in public health·2024
Same author

Exosomes Derived from hucMSCs Primed with IFN-γ Suppress the NF-κB Signal Pathway in LPS-Induced ALI by Modulating the miR-199b-5p/AFTPH Axis.

Cell biochemistry and biophysics·2024

Related Experiment Video

Updated: Jul 9, 2025

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

6.5K

Nanomaterials for brain metastasis.

Zhenhao Zhao1, Yun Chen1, Tao Sun1

  • 1Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|December 8, 2023
PubMed
Summary
This summary is machine-generated.

Brain metastasis is difficult to treat due to its unique environment and the blood-brain barrier. Nanomaterials offer a promising approach for targeted brain cancer therapies, improving treatment strategies.

Keywords:
BBB/BTB penetrationBrain metastasisImmunotherapyMicroenvironment regulationNanomaterialsTarget

More Related Videos

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.6K
Author Spotlight: Multimodal Imaging Strategies for Optimizing Drug Delivery and Early Detection in Glioblastoma Treatment
07:25

Author Spotlight: Multimodal Imaging Strategies for Optimizing Drug Delivery and Early Detection in Glioblastoma Treatment

Published on: March 1, 2024

2.4K

Related Experiment Videos

Last Updated: Jul 9, 2025

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

6.5K
Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.6K
Author Spotlight: Multimodal Imaging Strategies for Optimizing Drug Delivery and Early Detection in Glioblastoma Treatment
07:25

Author Spotlight: Multimodal Imaging Strategies for Optimizing Drug Delivery and Early Detection in Glioblastoma Treatment

Published on: March 1, 2024

2.4K

Area of Science:

  • Oncology
  • Nanomedicine
  • Cancer Biology

Background:

  • Brain metastasis significantly contributes to cancer patient mortality, with conventional treatments often failing to achieve complete remission.
  • The unique pathological environment of brain metastasis, including high mutation rates, immunosuppression, and the blood-brain barrier (BBB)/blood tumor barrier (BTB), presents significant therapeutic challenges.
  • Understanding the complex microenvironment and cellular roles in tumor spread is crucial for developing effective treatments.

Purpose of the Study:

  • To review current clinical treatment options for brain metastasis.
  • To explore the roles of different cells within the brain metastasis microenvironment.
  • To highlight the application of nanomaterials in advancing brain metastasis treatment strategies.

Main Methods:

  • Literature review of current clinical treatments for brain metastasis.
  • Analysis of cellular components and their functions in the brain metastasis microenvironment.
  • Examination of nanomaterial-based therapeutic approaches for brain metastasis.

Main Results:

  • Current treatments face limitations in achieving complete remission of brain metastasis.
  • The brain's unique pathological environment, including the BBB/BTB, complicates therapeutic interventions.
  • Nanomaterials demonstrate potential for targeted drug delivery and multimodal therapies tailored to brain metastasis characteristics.

Conclusions:

  • Developing novel therapeutic strategies that account for the specific pathological features of brain metastasis is essential.
  • Nanomaterials offer a versatile platform for overcoming challenges in treating brain metastasis.
  • Further research into nanomaterial applications holds promise for improving patient outcomes in brain metastasis.