Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defining a fibrinogen-to-factor XIII replacement ratio in an in-vitro model of dilutional coagulopathy.

Thrombosis research·2026
Same author

Tramadol and Its Influence on Platelet Function - An Ex Vivo Study.

Hamostaseologie·2026
Same author

Hyperfibrinolysis During Caesarean Section and Vaginal Delivery: A Prospective Cross-Sectional Study in the Delivery Room.

Journal of clinical medicine·2026
Same author

Erratum: "Diagnosis of Inherited Platelet Disorders": Update of the Interdisciplinary S2k-Guideline [*] of the Permanent Pediatric Commission of the Society of Thrombosis and Haemostasis Research (GTH e.V.).

Hamostaseologie·2025
Same author

Performance Evaluation of Different FIX Activity Assays for Determining Nonacog Beta Pegol (N9-GP, Refixia) Activity Using Reagent-/Platform-Specific Conversion Factors.

Hamostaseologie·2025
Same author

"Diagnosis of Inherited Platelet Disorders": Update of the Interdisciplinary S2k-Guideline [] of the Permanent Pediatric Commission of the Society of Thrombosis and Haemostasis Research (GTH e.V.).

Hamostaseologie·2025

Related Experiment Video

Updated: Jul 9, 2025

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

12.0K

Classic Light Transmission Platelet Aggregometry: Do We Still Need it?

Jennifer Gebetsberger1, Florian Prüller2

  • 1Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria.

Hamostaseologie
|December 8, 2023
PubMed
Summary

Light transmission aggregometry remains a gold standard for diagnosing inherited platelet disorders. This review discusses its pros and cons versus other methods, emphasizing its continued importance alongside genetic testing.

More Related Videos

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

897
Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

9.4K

Related Experiment Videos

Last Updated: Jul 9, 2025

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

12.0K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

897
Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

9.4K

Area of Science:

  • Hematology
  • Clinical Pathology
  • Diagnostic Laboratory Medicine

Background:

  • Light transmission aggregometry (LTA) has been the standard for diagnosing inherited platelet disorders for over 50 years.
  • Functional platelet assays are crucial for assessing platelet function, complementing other diagnostic methods.
  • Recent guidelines and advancements necessitate a re-evaluation of established diagnostic techniques.

Purpose of the Study:

  • To critically review the advantages and disadvantages of light transmission aggregometry compared to other functional platelet assays.
  • To discuss the role and necessity of light transmission aggregometry in the context of modern molecular genetic testing.
  • To provide an updated perspective on LTA in diagnosing inherited platelet disorders.

Main Methods:

  • Review of existing literature and guidelines concerning platelet function testing.
  • Comparative analysis of light transmission aggregometry with alternative functional assays (e.g., whole blood assays).
  • Discussion of the clinical utility of LTA in light of advancements in genetic diagnostics.

Main Results:

  • Light transmission aggregometry offers specific advantages in diagnosing inherited platelet disorders.
  • Certain limitations of LTA exist, particularly when compared to newer methodologies or in specific clinical scenarios.
  • Functional assays like LTA retain significant value even with the rise of molecular genetic testing.

Conclusions:

  • Light transmission aggregometry remains a vital tool for the diagnosis of inherited platelet disorders.
  • A comprehensive understanding of LTA's strengths and weaknesses is essential for accurate diagnosis.
  • Functional assays, including LTA, are necessary complements to molecular genetic testing for a complete diagnostic picture.