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Clinical and prognostic significance of CD27 and CD44 expression patterns in Egyptian pediatric patients with
Asmaa Abobakr1, Randa A Osman1, Mohamed A M Kamal2
1National Cancer Institute, Cairo University, Egypt.
Introduction:
The expression pattern of CD27 and CD44 was found to correlate with the differentiation stages of B cell precursors, which were known to be involved in a variety of immunological responses.
Aim Of The Study:
This study aimed to determine the biological significance of CD27 and CD44 expression in patients with B-precursor acute lymphoblastic leukemia (B-ALL), as well as their association with standard prognostic factors and therapeutic response.
Patients And Methods:
This case-control study included 60 pediatric patients newly diagnosed with B-ALL and 30 pediatric controls. The patient CD27 and CD44 levels were measured using the Beckman Coulter Navios Flow Cytometer.
Results:
Most malignant cells (91.6 %) expressed CD44, but only 50 % of the patients had CD27 expressed. The positive CD 44 expression was associated with unfavorable prognostic markers, including a decrease.
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