The interaction of obesity with susceptible gene polymorphisms in the relationship with mild cognitive impairment
Sun Xiaoya1, Xiang Yingjun1, Wang Liqun2
1Department of Clinical Psychology, Shenzhen Futian Center for Chronic Disease Control, Futian Center for Chronic Disease Control, Shenzhen, Guangdong, China.
Abstract:
Mild cognitive impairment (MCI) in the elderly is threatening the mental health of the elderly, and the interaction of some factors is worth exploring. This study aims to explore the interactions of obesity and gene polymorphisms in the relationship with MCI. A total of 2555 community resident dwellings include 444 participants who met MCI criteria recruited from the Ningxia province of China. Fourteen MCI-susceptible single nucleotide polymorphisms were detected using a high-throughput mass spectrometer. The interaction was examined by performing the multifactor dimensionality reduction model and unconditional logistic regression model. Logistic regression showed that obesity (OR = 1.42, 95%CI: 1.04-1.94), rs2075650G allele carrying (OR = 17.95, 95%CI: 1.32-244.95), rs11556505T allele carrying (OR = 0.06, 95%CI: 0.01-0.87) were statistically associated with MCI. Multifactor dimensionality reduction analysis showed a strong antagonistic effect between obesity and rs4402960 (Interaction dendrogram between obesity and rs4402960 is red) and a weak synergy effect on rs7901695 (Interaction dendrogram between obesity and rs7901695 is green). The hierarchical analysis showed obesity is a risk factor for MCI in the non-rs4402960T allele carrier group (OR = 1.55, 95%CI: 1.02-2.35). This study found that obesity is an independent risk factor for MCI, and the interactions with MCI-susceptible gene polymorphisms suggest a possible precision preventive intervention program should be developed to reduce the risk of MCI among individuals with obesity in the community.
Insights
Obesity is an independent risk factor for mild cognitive impairment (MCI) in the elderly. Interactions with specific gene variants suggest personalized prevention strategies may reduce MCI risk in obese individuals.
Area of Science:
- Gerontology
- Genetics
- Public Health
Background:
- Mild cognitive impairment (MCI) poses a significant threat to the mental health of the elderly population.
- Understanding the interplay of lifestyle factors and genetic predispositions is crucial for developing effective interventions.
Purpose of the Study:
- To investigate the interactive effects of obesity and specific gene polymorphisms on the risk of developing MCI.
- To identify potential targets for precision preventive interventions in community-dwelling elderly individuals.
Main Methods:
- Utilized logistic regression and multifactor dimensionality reduction (MDR) models to analyze data from 444 MCI patients and 2555 controls in Ningxia, China.
- Genotyped 14 MCI-susceptible single nucleotide polymorphisms (SNPs) using a high-throughput mass spectrometer.
- Examined interactions between obesity and SNPs, including rs2075650, rs11556505, rs4402960, and rs7901695.
Main Results:
- Obesity (OR=1.42) and carriage of the rs2075650 G allele (OR=17.95) were independently associated with increased MCI risk.
- Carriage of the rs11556505 T allele was associated with decreased MCI risk (OR=0.06).
- MDR analysis revealed antagonistic effects between obesity and rs4402960, and synergistic effects between obesity and rs7901695. Obesity was a risk factor in non-rs4402960T allele carriers (OR=1.55).
Conclusions:
- Obesity is confirmed as an independent risk factor for MCI in the elderly.
- The identified interactions between obesity and gene polymorphisms highlight the potential for tailored preventive strategies.
- Developing precision interventions targeting obese individuals, considering their genetic profiles, may effectively reduce MCI prevalence.
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