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Inflammatory burden, lifestyle and atherosclerotic cardiovascular disease: insights from a population based cohort

Benjamin Bay1,2,3, Christopher Blaum4, Caroline Kellner4,5

  • 1Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. b.bay@uke.de.

Scientific Reports
|December 8, 2023
PubMed

Insights

Lifestyle factors significantly impact cardiovascular risk. This study shows that more lifestyle-related risk factors (LRF) and wider atherosclerosis correlate with higher high-sensitivity C-reactive Protein (hsCRP) levels, highlighting the need for intervention.

Area of Science:

  • Cardiovascular disease research
  • Inflammation markers
  • Public health

Background:

  • High-sensitivity C-reactive Protein (hsCRP) is a cardiovascular risk factor.
  • Lifestyle-related risk factors (LRF) influence hsCRP levels.
  • The relationship between hsCRP, LRF, and atherosclerosis extent is not fully understood.

Purpose of the Study:

  • Investigate the interplay between hsCRP, LRF, and atherosclerotic disease.
  • Analyze hsCRP levels based on the number of affected vascular beds and LRF.
  • Examine associations in a contemporary population-based cohort.

Main Methods:

  • Cross-sectional study of the Hamburg City Health Study cohort (n=6765).
  • Defined affected vascular beds: coronary, peripheral, and cerebrovascular arteries.
  • Assessed LRF: physical inactivity, overweight, smoking, poor Mediterranean diet adherence.
  • Multivariable regression analyses with hsCRP as the dependent variable.

Main Results:

  • A stepwise increase in hsCRP was observed with increasing numbers of LRF.
  • hsCRP levels increased with the number of affected vascular beds.
  • Independent association found between higher LRF counts and elevated hsCRP across atherosclerosis extent.

Conclusions:

  • Increasing hsCRP concentrations are linked to both the number of LRF and the extent of atherosclerosis.
  • Optimizing lifestyle-related risk factors is crucial for managing cardiovascular risk.
  • Findings emphasize the importance of addressing multiple LRF for cardiovascular health.

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