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Published on: October 22, 2014
Association between endothelin-1, nitric oxide, and Gensini score in chronic coronary syndrome
Yujin Wang1,2,3, Yuqin Wang1, Tiaoxia Liu2
1Lanzhou University Second College of Clinical Medicine, Lanzhou, China.
Insights
Endothelin-1 (ET-1) and nitric oxide (NO) levels are strongly linked to chronic coronary syndrome (CCS) severity. Higher ET-1 and lower NO correlate with increased Gensini scores, indicating CCS progression.
Area of Science:
- Cardiology
- Vascular Biology
- Biochemistry
Background:
- Chronic coronary syndrome (CCS) presents a significant global health challenge, rooted in atherosclerosis and endothelial dysfunction.
- Endothelin-1 (ET-1) and nitric oxide (NO) are key endothelial-derived vasoactive substances implicated in CCS pathogenesis.
- The Gensini score (GS) quantifies CCS severity by assessing coronary lumen changes, stenosis degree, and lesion location.
Purpose of the Study:
- To investigate the relationship between Gensini score (GS) and serum levels of Endothelin-1 (ET-1) and nitric oxide (NO) in patients with CCS.
- To determine the predictive value of ET-1 and NO in assessing CCS disease severity.
Main Methods:
- A prospective study involving 71 patients diagnosed with CCS.
- Calculation of the Gensini score (GS) for each patient.
- Measurement of serum ET-1 and NO levels, alongside other laboratory parameters.
Main Results:
- Patients in the high GS group exhibited elevated ET-1 and reduced NO levels compared to the low GS group.
- GS demonstrated a positive correlation with ET-1 and negative correlations with NO, T4, and TSH.
- Multiple linear regression analysis identified ET-1 as the most significant predictor of GS.
Conclusions:
- A significant association exists between ET-1, NO, and the severity of CCS.
- The combined assessment of ET-1, NO, and GS serves as a crucial predictor for CCS disease severity.
Background:
Chronic coronary syndrome (CCS) is a major public health burden; its pathogenesis involves atherosclerosis and endothelial dysfunction. Endothelin-1 (ET-1) and nitric oxide (NO) are vasoactive substances synthesized by endothelial cells that play a crucial role in CCS development. The Gensini score (GS) is used for evaluating CCS severity based on lumen segment changes, stenosis degree, and coronary stenosis site.
Methods:
This prospective study included 71 patients with CCS; we evaluated the relationships between GS and ET-1 and NO serum levels were evaluated in these patients. The GS was calculated for all patients. Serum ET-1 & NO levels among other laboratory parameters were measured.
Results:
The high GS group had higher ET-1 and relatively NO expressions in the than the low GS group. GS was positively correlated with ET-1 and negatively correlated with NO, T4, and TSH levels. The results of the multiple linear regression analysis showed that ET-1 had the most significant effect on GS.
Conclusions:
We found a strong association between ET-1, NO, and CCS severity. A combination of ET-1, NO, and GS is an essential predictor of CCS disease severity.
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