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Updated: Jul 9, 2025

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The role of N-methyladenosine modification in acute and chronic kidney diseases

Saiqi Qi1, Jie Song1, Linjun Chen2

  • 1The College of Medical Technology, Shanghai University of Medicine & Health Sciences, 279 Zhouzhu Highway, Pudong New Area, Shanghai, 201318, People's Republic of China.

Molecular Medicine (Cambridge, Mass.)
|December 8, 2023
PubMed

Insights

N6-methyladenosine (m6A) RNA modification is crucial in regulating gene expression and is increasingly linked to kidney diseases. This review explores m6A

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Nephrology

Background:

  • N6-methyladenosine (m6A) is a prevalent RNA modification impacting gene expression.
  • m6A dynamics involve writers, readers, and erasers.
  • m6A dysregulation is implicated in various kidney pathologies.

Purpose of the Study:

  • To review the physiological and pathological roles of m6A modification in kidney diseases.
  • To elucidate the molecular mechanisms of m6A in kidney disease development.
  • To provide insights for clinical diagnosis and management of kidney diseases.

Main Methods:

  • Literature review of studies on m6A modification and kidney diseases.
  • Analysis of molecular mechanisms underlying m6A's role in renal pathophysiology.
  • Synthesis of current evidence on m6A in uremia, I/R injury, drug-induced injury, and diabetic nephropathy.

Main Results:

  • m6A modification plays significant roles in splicing, RNA export, translation, and stability.
  • m6A is involved in the pathogenesis of uremia, ischemia-reperfusion kidney injury, drug-induced kidney injury, and diabetic nephropathy.
  • Specific m6A 'writers', 'readers', and 'erasers' are key players in kidney disease progression.

Conclusions:

  • m6A modification is a critical regulator in kidney disease.
  • Targeting m6A pathways offers potential therapeutic strategies for kidney diseases.
  • Further research into m6A mechanisms can improve kidney disease diagnosis and treatment.
Keywords:
Acute kidney injuryChronic kidney diseasem6A modification

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