Primary Chronic Sclerosing Osteomyelitis: A New Diagnostic Tool
Anne-Sophie Lacagne1, Laurence May1, Marie Nicod Lalonde2
1Department of Oral and Maxillofacial Surgery, Lausanne University Hospital, 1005 Lausanne, Switzerland.
Diagnosing primary chronic sclerosing osteomyelitis (PCSO) is challenging. Combining three-phase bone scintigraphy and anti-granulocyte antibody scintigraphy helps differentiate PCSO from infection, enabling earlier diagnosis and treatment.
Area of Science:
- Oral and Maxillofacial Surgery
- Nuclear Medicine
- Skeletal Imaging
Background:
- Primary chronic sclerosing osteomyelitis (PCSO) presents diagnostic and therapeutic challenges due to its rarity.
- Distinguishing PCSO from infectious osteomyelitis is crucial for appropriate patient management.
Purpose of the Study:
- To evaluate the utility of a novel diagnostic approach for primary chronic sclerosing osteomyelitis.
- To assess the combined efficacy of three-phase bone scintigraphy and anti-granulocyte antibody scintigraphy in diagnosing PCSO.
Main Methods:
- Retrospective analysis of four patients diagnosed with chronic mandibular pain between 2010 and 2018.
- All patients underwent three-phase bone scintigraphy and anti-granulocyte antibody scintigraphy.
Main Results:
- Three-phase bone scintigraphy indicated radiotracer uptake at the site of pain.
- Anti-granulocyte antibody scintigraphy showed no abnormal uptake, suggesting a non-infectious etiology.
Conclusions:
- The combination of three-phase bone scintigraphy and anti-granulocyte antibody scintigraphy aids in diagnosing PCSO.
- This combined imaging strategy can prevent unnecessary investigations and treatments, facilitating early diagnosis.
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