Related Experiment Video
Updated: Jul 9, 2025
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Tracking Bispecific Antibody-Induced T Cell Trafficking Using Luciferase-Transduced Human T Cells
Published on: May 12, 2023
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Bispecific antibody therapies
Luiz Henrique de Assis1, Daniel El Fassi2, Martin Hutchings2,3
1Unidade de Terapia Celular, Hospital São Rafael, Salvador, Bahia, Brasil.
Hematology. American Society of Hematology. Education Program
|December 9, 2023
Summary
Bispecific antibodies (BsAbs) for blood cancers cause common hematological toxicities. Early management of neutropenia and hypogammaglobulinemia is key to reducing patient harm.
Area of Science:
- Hematology
- Oncology
- Immunotherapy
Background:
- Cancer treatment is shifting towards targeted agents and immunotherapies like bispecific antibodies (BsAbs).
- These advanced therapies present unique and potentially severe side effect profiles.
- Hematological toxicities associated with BsAbs require a comprehensive review and management strategy.
Conclusions:
- Hematological toxicities are a primary concern with bispecific antibody (BsAb) treatments.
- Proactive management and prevention strategies for neutropenia and hypogammaglobulinemia are crucial.
- Effective management can mitigate morbidity and mortality associated with BsAb-induced hematological toxicities.
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