A rational approach to functional high-risk myeloma

Area of Science:

• Hematology
• Oncology
• Clinical Medicine

Background:

• Multiple myeloma exhibits significant clinical and biological heterogeneity, impacting patient survival.
• Current staging systems may be suboptimal for identifying all high-risk patients.
• Functional high-risk patients, defined by suboptimal treatment response, face poor prognoses.

Conclusions:

• There is a critical unmet need for the prompt identification and consistent definition of functional high-risk multiple myeloma patients.
• Improved risk stratification and targeted management strategies are required.
• Further research into the specific characteristics and optimal treatment of this patient subset is warranted.