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CAR T-cell therapy in aggressive lymphomas-identifying prognostic and predictive markers

Alberto Mussetti1, Nicole Fabbri2, Anna Sureda1,3

  • 1Department of Hematology, Catalan Institute of Oncology, Hospital Duran i Reynals, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

Hematology. American Society of Hematology. Education Program
|December 9, 2023
PubMed
Summary

Identifying prognostic factors before, during, and after anti-CD19 CAR T-cell therapy is key for improving outcomes in relapsed or refractory large B-cell lymphomas. Personalized treatment strategies are essential for patients undergoing this advanced therapy.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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