Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Histone Modification02:32

Histone Modification

13.3K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
13.3K
Epigenetic Regulation01:37

Epigenetic Regulation

3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the Role of Hypusine Signaling in Vascular Smooth Muscle Cells for Mitigating Restenosis in Coronary Artery Disease.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Correction to: Breast Cancer Reveals Latent <i>BMPR2</i>-Related Susceptibility to Pulmonary Hypertension.

Circulation·2026
Same author

Pulmonary Arterial Hypertension Induces a Metabolic and Inflammatory Hepatopathy.

bioRxiv : the preprint server for biology·2026
Same author

Critical Contribution of Cardiac Myofibroblasts in Right Ventricular Failure and the Role of UCP2 SNPs in the Predisposition to RV Decompensation in Pulmonary Arterial Hypertension.

Circulation·2026
Same author

Alternative Polyadenylation Signatures Distinguish Maladaptive Right Ventricular Remodeling in Pulmonary Hypertension: Implications for RNA-Based Diagnostics and Therapeutics.

British journal of biomedical science·2026
Same author

Cardiomyocyte NLRP3 signaling in right heart failure is sexually dimorphic via estrogen receptor α.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jul 9, 2025

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

8.2K

Right Ventricle and Epigenetics: A Systematic Review.

Victoria Toro1, Naomie Jutras-Beaudoin1, Olivier Boucherat1

  • 1Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec (CRIUCPQ), Québec, QC G1V 4G5, Canada.

Cells
|December 9, 2023
PubMed
Summary

Epigenetic modifications critically influence right ventricle (RV) function and dysfunction. This review highlights current knowledge and discrepancies in epigenetic research concerning the RV.

Keywords:
DNA methylationarrhythmogeniccardiomyopathyepigeneticfibrosishistonelncRNAmicroRNApreclinical modelpulmonary hypertensionright ventriclesystemic ventricletetralogy of Fallot

More Related Videos

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart
08:22

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart

Published on: April 15, 2020

18.4K
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

3.6K

Related Experiment Videos

Last Updated: Jul 9, 2025

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

8.2K
Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart
08:22

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart

Published on: April 15, 2020

18.4K
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

3.6K

Area of Science:

  • Cardiovascular Biology
  • Epigenetics
  • Right Ventricle Physiology

Background:

  • The right ventricle (RV) plays a vital role in overall functional status and prognosis across various conditions.
  • Epigenetic regulation, including DNA methylation, histone modification, and non-coding RNAs, is increasingly recognized as a key factor in RV development and function.
  • Understanding RV epigenetic mechanisms is crucial for addressing RV pathological dysfunction.

Approach:

  • A systematic review of English literature from PubMed (inception to January 1, 2023) was conducted.
  • Studies investigating epigenetic modifications related to RV development or dysfunction, irrespective of the underlying pathology, were included.
  • 109 studies were selected from 817 screened, with 69 utilizing human samples.

Key Points:

  • The review synthesizes current knowledge on epigenetic modifications impacting RV function and dysfunction in human and preclinical models.
  • A significant number of studies (37) proposed epigenetic-based therapeutic interventions, though none have reached clinical trial stages.
  • A notable discrepancy exists between studies regarding the reported effects of specific epigenetic modifications on RV function and development.

Conclusions:

  • Epigenetic mechanisms are central to RV biology and pathology.
  • Further research is needed to reconcile conflicting findings and translate epigenetic insights into clinical applications for RV diseases.
  • Standardization of research methodologies may be required to address observed discrepancies in the field.