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Advances of Protein Palmitoylation in Tumor Cell Deaths

Xiangyi Lin1, Yuxuan Shi1, Yuxin Zhan1

  • 1Department of Human Cell Biology and Genetics, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen 518000, China.

Cancers
|December 9, 2023
PubMed

Insights

Palmitoylation plays a key role in cancer cell death and growth. New therapies targeting palmitoylation, like Ezurpimtrostat, show promise for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Palmitoylation, a lipid modification, is increasingly recognized for its role in cancer progression and cell death.
  • The DHHC enzyme family and depalmitoylation enzymes like PPT1 are critical regulators of palmitoylation.
  • Advances in detection methods have improved the study of palmitoylation dynamics.

Purpose of the Study:

  • To comprehensively review the role of palmitoylation in various cancer cell death pathways.
  • To explore the connection between palmitoylation, tumorigenesis, and depalmitoylation.
  • To highlight novel therapeutic agents targeting palmitoylation in cancer.

Main Methods:

  • Literature review of existing studies on palmitoylation in oncology.
  • Analysis of the mechanisms involving DHHC enzymes and depalmitoylation.
  • Discussion of emerging therapeutic agents and detection methodologies.

Main Results:

  • Palmitoylation is intricately linked to tumorigenesis and diverse cell death modalities.
  • DHHC enzymes catalyze palmitoylation, while enzymes like PPT1 mediate depalmitoylation.
  • Ezurpimtrostat (GNS561) and dimeric chloroquine (DC661) represent promising therapeutic strategies.

Conclusions:

  • Palmitoylation is a critical regulator of cancer cell fate with significant therapeutic potential.
  • Targeting palmitoylation pathways offers a novel approach for cancer treatment.
  • Further research into palmitoylation dynamics will deepen our understanding of cancer biology.
Keywords:
apoptosisautophagyferroptosisprotein palmitoylationpyroptosis

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