Related Experiment Video
Updated: Jul 9, 2025
12:24
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
5.2K
Comprehensive Profiling and Therapeutic Insights into Differentially Expressed Genes in Hepatocellular Carcinoma
Wesley Ladeira Caputo1, Milena Cremer de Souza1, Caroline Rodrigues Basso2
1Post Graduation Program in Experimental Pathology, State University of Londrina (UEL), Londrina 86057-970, PR, Brazil.
Cancers
|December 9, 2023
Summary
This study identifies key genes and potential drug candidates for hepatocellular carcinoma (HCC) by analyzing gene expression data. Drug repurposing offers new therapeutic avenues for liver cancer treatment.
Area of Science:
- Genomics
- Oncology
- Pharmacology
Background:
- Hepatocellular carcinoma (HCC) is a prevalent liver cancer requiring novel therapeutic strategies.
- Drug repurposing offers an alternative to traditional drug development for HCC.
Purpose of the Study:
- To identify differentially expressed genes (DEGs) in HCC.
- To explore drug repurposing opportunities for HCC treatment.
Main Methods:
- Analyzed microarray and RNA-seq data to identify DEGs between tumor and non-tumor liver tissues.
- Utilized topological analysis to identify hub genes and regulatory transcription factors.
- Employed computational approaches for drug repurposing analysis.
Main Results:
- Identified DEGs linked to metal ion processes (zinc, cadmium, copper) and mitotic/kinase activities.
- Discovered 25 hub genes and their regulatory transcription factors.
- Proposed potential therapeutic chemicals including alvocidib, doxorubicin, and teniposide for HCC.
Conclusions:
- This multi-omic study provides insights into HCC molecular alterations.
- Identified potential therapeutic targets and drug repurposing candidates for HCC.
