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Related Experiment Video

Updated: Jul 9, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Friedelin: Structure, Biosynthesis, Extraction, and Its Potential Health Impact.

Santosh Kumar Singh¹, Shweta Shrivastava², Awdhesh Kumar Mishra³

¹Department of Biotechnology, ARKA Jain University, Jamshedpur 832108, Jharkhand, India.

Molecules (Basel, Switzerland)

|December 9, 2023

Summary

This summary is machine-generated.

Friedelin, a natural compound from plants, shows significant anti-inflammatory, antioxidant, and anticancer effects. Advanced methods like CRISPR/Cas9 are enabling its production for potential pharmaceutical applications.

Keywords:

anticancer antimicrobial extraction methods friedelin neuroprotective phytochemicals

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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

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Published on: August 14, 2019

Area of Science:

Phytochemistry
Pharmacology
Biotechnology

Background:

Friedelin (friedelan-3-one) is a pentacyclic triterpene found in diverse plant species, mosses, and lichens.
It is abundant in cork tissues and leaf materials of genera like Celastraceae, Asteraceae, Fabaceae, and Myrtaceae.
Friedelin exhibits various pharmacological activities, including anti-inflammatory, antioxidant, anticancer, and antimicrobial effects, and agricultural benefits.

Purpose of the Study:

To review the structural interpretation, biosynthesis, and physicochemical properties of friedelin.
To summarize the quantification methods and diverse pharmacological significance of friedelin.
To highlight recent advancements in friedelin production and its potential as a pharmaceutical agent.

Main Methods:

Extraction of friedelin using environmentally friendly techniques such as ultrasound, microwave, supercritical fluid, ionic liquid, and acid hydrolysis.
Production of friedelin via genetically engineered yeast using CRISPR/Cas9 technology and gene overexpression plasmids.
Analysis of structural interpretation, biosynthesis, physicochemical properties, and quantification.

Main Results:

Friedelin possesses a wide range of pharmacological effects, including anti-inflammatory, antioxidant, anticancer, and antimicrobial activities.
It demonstrates agricultural utility through its anti-insect effect and ability to modify soil microbial ecology.
Engineered yeast systems offer a promising avenue for scalable friedelin production with low cytotoxicity.

Conclusions:

Friedelin is a valuable phytochemical with significant therapeutic and agricultural potential.
Advanced biotechnological approaches are crucial for meeting the growing demand for friedelin.
Its low cytotoxicity makes friedelin a strong candidate for drug development.