Koninginins X-Z, Three New Polyketides from Trichoderma koningiopsis SC-5
Weiwei Peng1,2, Jianbing Tan1,2, Zihuan Sang1,2,3
1Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Molecules (Basel, Switzerland)
|December 9, 2023
Abstract:
Koninginins X-Z (1-3), three novel polyketides, were isolated from the solid fermentation of the endophytic fungus Trichoderma koningiopsis SC-5. Their structures, including the absolute configurations, were comprehensively characterized by a combination of NMR spectroscopic methods, HRESIMS, 13C NMR, DFT GIAO 13C NMR, and electronic circular dichroism calculations as well as single crystal X-ray diffraction. In addition, all the compounds were evaluated for antifungal activity against Candida albicans.
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