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On-Demand ICS + FABA Combinations in 6-11-Year-Old Children.
Elsy M Navarrete-Rodríguez1, Blanca E Del-Rio-Navarro1, Désirée Larenas-Linnemann2
1Secretaría de Salud, Hospital Infantil de México Federico Gómez, Servicio de Alergia e Inmunología Clínica, Ciudad de Mexico 06760, Mexico.
Journal of Clinical Medicine
|December 9, 2023
Summary
New asthma treatment strategies, like inhaled corticosteroids (ICS) plus fast-acting beta-agonists (FABA) as a reliever, show benefits in children aged 6-11. This approach combines anti-inflammatory and bronchodilator effects for improved asthma management in younger patients.
Area of Science:
- Pediatric Pulmonology
- Pharmacology
- Asthma Therapeutics
Background:
- Recent asthma treatment advances include "anti-inflammatory reliever" strategies combining inhaled corticosteroids (ICS) and short-acting beta-agonists.
- International guidelines have incorporated these strategies, primarily based on evidence in patients over 12 years old.
- Limited evidence exists for the efficacy and safety of these combined therapies in younger children.
Purpose of the Study:
- To review and analyze the available information on the use of ICS plus fast-acting beta-agonist (FABA) combination therapy in children aged 6 to 11 years.
- To assess the potential benefits of this treatment approach in a pediatric population with asthma.
- To address the scarcity of evidence regarding ICS + FABA use in this specific age group.
Main Methods:
- Systematic review of published clinical trials investigating ICS + FABA combination therapy in children aged 6-11.
- Analysis of data from studies utilizing specific ICS/FABA combinations, such as beclomethasone/albuterol and budesonide/formoterol.
- Evaluation of reported efficacy and safety outcomes from the included trials.
Main Results:
- Three published trials provide significant insights into ICS + FABA use in children aged 6-11.
- Studies using beclomethasone + albuterol and budesonide + formoterol suggest therapeutic benefits.
- The available data indicates positive outcomes associated with this combined treatment approach in the target pediatric population.
Conclusions:
- The ICS + FABA combination therapy demonstrates significant potential benefits for asthma management in children aged 6 to 11 years.
- Despite limited trial numbers, existing evidence supports the consideration of this "anti-inflammatory reliever" strategy in this age group.
- Further research is warranted to expand the evidence base for ICS + FABA use in pediatric asthma patients.
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