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Related Concept Videos

Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.

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Substantiating Appropriate Motion Capture Techniques for the Assessment of Nordic Walking Gait and Posture in Older Adults
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Characterizing Movement Patterns of Older Individuals with T2D in Free-Living Environments Using Wearable

Tal Yahalom-Peri1,2, Veronika Bogina3,4, Yamit Basson-Shleymovich2,5

  • 1Division of Endocrinology, Sheba Medical Center, Ramat-Gan 5266202, Israel.

Journal of Clinical Medicine
|December 9, 2023
PubMed
Summary

Older adults with Type 2 Diabetes and low physical capacity exhibit distinct movement patterns and reduced activity. This study identifies novel ways to detect physical decline in free-living individuals with Type 2 Diabetes.

Keywords:
accelerometermovement patternsphysical capacitytype 2 diabetes

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Area of Science:

  • Gerontology
  • Metabolic Diseases
  • Biomedical Engineering

Background:

  • Type 2 Diabetes (T2D) is linked to decreased muscle mass, strength, and function, increasing frailty risk in older adults.
  • Understanding movement patterns (MPs) in relation to physical capacity (PC) is crucial for managing T2D-related complications.

Purpose of the Study:

  • To analyze movement patterns (MPs) in older individuals with Type 2 Diabetes (T2D) across different levels of physical capacity (PC).
  • To identify accelerometer-derived features that differentiate PC levels in a free-living setting.

Main Methods:

  • A cross-sectional study involving 103 older adults (≥60 years) with T2D, using continuous glucose monitoring and activity tracking for one week.
  • Participants were categorized into low (LPC), medium (MPC), and normal (NPC) physical capacity groups based on tests.
  • Movement patterns and physical activity data were analyzed using Kruskal-Wallis and Dunn post-hoc tests (p < 0.05), with Python (pandas, scipy.stats) for analysis.

Main Results:

  • Low physical capacity (LPC) participants showed altered movement: lower medio-lateral, higher vertical/antero-posterior acceleration, and higher root mean square values.
  • LPC group exhibited significantly less time in moderate-to-vigorous physical activity (MVPA) and fewer daily steps compared to MPC and NPC groups.
  • Distinct movement patterns and lower activity levels were observed in the LPC group.

Conclusions:

  • Older adults with T2D and low PC demonstrate unique movement characteristics and reduced physical activity in their daily lives.
  • Accelerometer-derived features can effectively differentiate between varying PC levels in T2D patients.
  • This research offers a novel, labor-free method for detecting physical deterioration and low PC in T2D individuals based on real-world behavior.