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The Correlation between Elevated HDL-Cholesterol, Body Mass Index, and Presence of Thyroid Nodules: A Retrospective

Cafer Zorkun1, Kenan Yalta2, Alara Eren3

  • 1Department of Cardiology, Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey.

Journal of Clinical Medicine
|December 9, 2023
PubMed

Insights

Elevated high-density lipoprotein-cholesterol (HDL-cholesterol) may indicate thyroid nodules, particularly in women with higher body mass index (BMI). This finding suggests HDL-cholesterol might be an indicator, not a cardiovascular protective marker, in this context.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Medical Diagnostics

Background:

  • Elevated high-density lipoprotein-cholesterol (HDL-cholesterol) is linked to adverse outcomes, but its association with thyroid nodules is not well-established.
  • Thyroid nodules are common, and understanding their predictors is crucial for patient management.

Purpose of the Study:

  • To investigate the correlation between elevated HDL-cholesterol levels and the presence of thyroid nodules.
  • To identify demographic and clinical factors associated with thyroid nodules in relation to HDL-cholesterol.

Main Methods:

  • Retrospective analysis of 677 patients categorized by body mass index (BMI) <25, 25-29, and ≥30.
  • Evaluation of demographic data, heart rate, and HDL-cholesterol levels.
  • Multivariate regression analysis to identify independent predictors of thyroid nodules.

Main Results:

  • Thyroid nodules were found in 67.1% of the cohort; left ventricle diastolic dysfunction (LVDD) in 58.1%.
  • Body mass index (BMI), heart rate, and HDL-cholesterol were independent predictors of thyroid nodules (p=0.000 for all).
  • Thyroid nodules were more prevalent in females, especially with higher BMI (OR=1.048-1.115), but not in males.

Conclusions:

  • Elevated HDL-cholesterol may serve as an indicator for thyroid nodules.
  • The precise mechanisms linking HDL-cholesterol and thyroid nodules require further investigation.
  • Findings suggest HDL-cholesterol's role may differ from its typical cardiovascular protective function in this context.
Abstract

Keywords:
HDL-cholesterolatherosclerosisbody mass indexcardiovascular protectionthyroid nodules

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