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Animal Models in Eye Research: Focus on Corneal Pathologies
Alexis Loiseau1, Gabrielle Raîche-Marcoux1, Cloé Maranda1
1Faculty of Medicine, Department of Ophthalmology and Otolaryngology-Head and Neck Surgery, CHU de Québec Research Center, Université Laval, Québec, QC G1S 4L8, Canada.
International Journal of Molecular Sciences
|December 9, 2023
Summary
Selecting appropriate animal models is crucial for advancing research into corneal diseases, the fifth leading cause of blindness. These models aid in understanding disease mechanisms and testing new therapies for human patients.
Area of Science:
- Ophthalmology
- Comparative Medicine
- Regenerative Medicine
Background:
- The cornea, essential for vision, is vulnerable to injury and disease due to its exposed nature.
- Corneal diseases are a significant global health issue, ranking as the fifth leading cause of blindness worldwide.
- Therapeutic product development for ocular diseases requires rigorous safety assessments using animal models.
Purpose of the Study:
- To review the selection criteria for animal models in ocular research.
- To discuss the utility of current animal models for human corneal pathologies.
- To highlight the role of animal models in translational research for corneal diseases.
Main Methods:
- Literature review focusing on animal models for ocular research.
- Analysis of existing studies on animal models relevant to human corneal diseases.
- Evaluation of the translational potential of animal models in ophthalmology.
Main Results:
- Animal models possess unique characteristics relevant to ocular research and disease mechanisms.
- Current animal models offer valuable insights into human corneal pathologies.
- These models serve as critical tools for assessing therapeutic efficacy and safety.
Conclusions:
- Appropriate animal model selection is vital for advancing the understanding and treatment of corneal diseases.
- Human-relevant animal models are indispensable for translating basic research findings into clinical applications.
- Further development of reliable animal models will accelerate therapeutic innovation for vision impairment.
