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Molecular Mechanisms Associated with Aging Kidneys and Future Perspectives
Min-Jee Jo1,2, Joo-Kyung Lee1, Ji-Eun Kim1
1Department of Internal Medicine, Korea University College of Medicine, Korea University Guro Hospital, Seoul 08308, Republic of Korea.
International Journal of Molecular Sciences
|December 9, 2023
Summary
As people age, kidney function declines, showing reduced size and filtration. This review explores aging kidney mechanisms to find future treatment targets for age-related kidney disease.
Area of Science:
- Gerontology
- Nephrology
- Molecular Biology
Background:
- The global elderly population is rapidly expanding.
- Age-related organ dysfunction is a critical research area.
- Kidneys are significantly impacted by the aging process.
Purpose of the Study:
- To review the functional and molecular mechanisms underlying kidney aging.
- To identify potential therapeutic targets for age-related kidney dysfunction.
Main Methods:
- Literature review of studies on kidney aging.
- Analysis of molecular and functional changes in aged kidneys.
Main Results:
- Aged kidneys exhibit reduced size, decreased glomerular filtration rate, and altered renal blood flow.
- Increased inflammation and fibrosis are characteristic of aging kidneys.
- Specific molecular pathways involved in kidney aging have been identified.
Conclusions:
- Understanding kidney aging mechanisms is essential for developing effective treatments.
- Targeting specific molecular pathways may mitigate age-related kidney decline.
- Further research is needed to translate these findings into clinical applications for kidney health in the elderly.
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