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Updated: Jul 9, 2025
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Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
897
The platelet storage lesion, what are we working for?
Cheng Liu1, Yang Su1, Wanwan Guo1
1Peking University Third Hospital, Beijing, China.
Journal of Clinical Laboratory Analysis
|December 9, 2023
Summary
Understanding platelet storage lesions (PSLs) is key to improving platelet concentrate quality and transfusion safety. Research into PSL mechanisms and novel storage methods aims to extend platelet shelf life and enhance patient outcomes.
Area of Science:
- Transfusion Medicine
- Hematology
- Biotechnology
Background:
- Platelet concentrate (PC) transfusions are vital for managing bleeding in various clinical conditions.
- Current PC shelf life is limited to 5 days due to bacterial contamination and platelet storage lesions (PSLs) at room temperature.
- Understanding PSLs is crucial for improving platelet quality and transfusion safety.
Purpose of the Study:
- To review mechanistic research on PSLs.
- To explore the relationship between PSLs and clinical practice.
- To provide insights for future research directions in platelet storage and transfusion.
Main Methods:
- Literature search on PubMed and Web of Science using keywords "PSL" and "platelet transfusion."
- Categorization of literature based on research content.
- Iterative searching based on keywords from categorized sections.
Main Results:
- PSLs are studied through changes in platelet morphology, surface molecules, BMRs, metabolism, proteins, and RNA.
- Novel storage conditions, including platelet additive solutions (PAS) and cold storage, are being investigated.
- Two main strategies for high-quality platelet production: simulating in vivo conditions or maintaining low activity at low temperatures.
Conclusions:
- Understanding PSLs aids in identifying intervention targets.
- PSL research helps assess therapeutic effects for different patient groups.
- Improved understanding facilitates safer and more effective platelet transfusions.
Keywords:
biological response modifierscold storageplatelet additive solutionsplatelet storage lesionsplatelet transfusionMore Related Videos
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