Mass Spectrometry in Proteomics: Technologies, Methods, and Research Applications for the Life Sciences
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Updated: Jul 9, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
Published on: November 15, 2017
Paolo Nanni1, Peter Gehrig2, Ralph Schlapbach3
1Functional Genomics Center Zurich, University of Zurich / ETH Zurich. paolo.nanni@fgcz.uzh.ch.
Abstract:
Mass spectrometry is a powerful tool in the hand of life science researchers, who constantly develop and apply new methods for the investigation of biomolecules, such as proteins, peptides, metabolites, lipids, and glycans. In this review, we will discuss the importance of mass spectrometry for the life science sector, with a special focus on the most relevant current applications in the field of proteomics. Moreover, we will comment on the factors that research groups should consider when setting up a mass spectrometry laboratory, and on the fundamental role played by academic core facilities and industrial service providers.
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