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Updated: Jul 9, 2025

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Nano-optogenetic CAR-T Cell Immunotherapy.

Nhung Thi Nguyen¹, Siyao Liu¹, Gang Han²

¹Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.

Methods in Molecular Biology (Clifton, N.J.)

|December 9, 2023

Summary

A new nano-optogenetic method offers precise control over chimeric antigen receptor (CAR)-T cell immunotherapy. This approach uses light-sensitive CAR-T cells and nanoparticles to enhance cancer treatment safety and efficacy.

Keywords:

CAR T cell Cancer immunotherapy Nano-optogenetics Near-infrared light Synthetic immunology Upconversion nanoparticles Wireless control

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Area of Science:

Immunotherapy
Nanotechnology
Optogenetics

Background:

Chimeric antigen receptor (CAR)-T cell immunotherapy is a promising cancer treatment.
Conventional CAR-T cell therapies face challenges with safety and precise control, leading to side effects like cytokine release syndrome (CRS) and off-tumor toxicity.
Current methods lack the spatiotemporal precision needed to manage CAR-T cell activity effectively.

Purpose of the Study:

To develop a novel method for precise spatiotemporal control of CAR-T cell activity.
To enhance the safety and efficacy of CAR-T cell immunotherapy.
To overcome the limitations of conventional CAR-T cell therapies.

Main Methods:

Development of synthetic light-sensitive CAR-T cells.
Utilizing upconversion nanoparticles as in situ nanotransducers.
Employing near-infrared light for wireless control of CAR-T cell activity.

Main Results:

Demonstrated spatiotemporal control over CAR-T cell activity using a nano-optogenetic system.
Enabled precise targeting and activation of CAR-T cells via near-infrared light.
Showcased potential for improved safety and efficacy in CAR-T cell immunotherapy.

Conclusions:

The developed nano-optogenetic approach provides unprecedented control over CAR-T cell immunotherapy.
This system offers a promising strategy to mitigate safety concerns like CRS and off-tumor toxicity.
This technology paves the way for safer and more effective CAR-T cell-based cancer treatments.