Related Experiment Video
Updated: Jul 8, 2025
Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
Published on: May 17, 2024
Nipple necrosis rate with submuscular versus prepectoral implant-based reconstruction in nipple sparing mastectomy:
Ayat ElSherif1, Steven Bernard2, Risal Djohan2
1Division of Breast Surgery, Department of General Surgery, Cleveland Clinic, Cleveland, OH, USA.
Background:
This study aims to compare the rate of nipple necrosis between the submuscular (SM) versus the prepectoral (PP) implant placement after immediate breast reconstruction (IBR).
Methods:
An institutional review board-approved database was reviewed of patients who underwent nipple sparing mastectomy (NSM) with IBR at our institution between 2016 and 2019. Patients who had SM versus PP IBR were compared. Incidence of nipple necrosis was evaluated between the two groups.
Results:
A total of 525 NSM with IBR were performed in 320 patients with SM reconstruction in 61% (n = 322) and PP in 39% (n = 203) of the mastectomies. Overall, 43 nipples experienced some form of necrosis with 1% of mastectomies experiencing nipple loss. There was no difference between SM group and PP group at the rate of nipple necrosis (9 % vs 7 %, P = 0.71).
Conclusion:
In patients undergoing NSM with IBR, the rate of nipple necrosis, nipple loss or complications did not differ between groups whether the implant was placed SM or PP, supporting the safety of this newer procedure.
