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Microarray molecular mapping of horses with severe asthma.

Samuel J White¹, Laurent Couetil², Eric A Richard^3,4

¹Nottingham Trent University, Nottinghamshire, UK.

Journal of Veterinary Internal Medicine

|December 10, 2023

Summary

Severe equine asthma (SA) diagnosis is improved by identifying specific allergens using microarray profiling. Sensitization profiles vary geographically, emphasizing local environmental exposures in horses.

Keywords:

IgE One Health allergen microarray severe equine asthma

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Published on: November 1, 2014

Area of Science:

Veterinary Immunology
Equine Respiratory Diseases
Environmental Allergy

Background:

Severe asthma (SA) in horses is a common allergic respiratory condition.
Elevated allergen-specific immunoglobulin E (IgE) is characteristic of SA.
Understanding the exposome's impact on IgE profiles is crucial for SA diagnostics and therapeutics.

Purpose of the Study:

To investigate geographic variations in allergen sensitization profiles in horses with SA.
To identify specific allergens associated with SA across different regions.
To evaluate the utility of microarray profiling and mathematical modeling for SA classification.

Main Methods:

Analyzed 35 sport horses from France, the United States, and Canada (SA and control groups).
Employed serological antigen microarray profiling to assess sensitization profiles.
Utilized Partial Least Square-Discriminant Analysis (PLS-DA) and frequency analysis for allergen identification and classification.

Main Results:

PLS-DA models demonstrated high discriminatory power for SA in Canada and France, but not the US.
Hev b 5.0101, Cyn D, Der p 2, and Rum cr were identified as common allergens across all regions.
Significant variability in sensitization profiles was observed between geographical locations.

Conclusions:

Microarray profiling effectively identifies SA-associated allergens in horses.
Mathematical modeling aids in SA classification and highlights geographic variability.
Local environmental exposures are critical factors influencing allergen prevalence and SA in horses.