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Calculi in renal transplants.

B S Lucas, J E Castro

    British Journal of Urology
    |August 1, 1978
    PubMed
    Summary

    Kidney transplant recipients can develop stones in their new kidneys. Prompt treatment of hypercalcemia, secondary hyperparathyroidism, or urinary issues can prevent further stone formation and maintain kidney function.

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    Area of Science:

    • Nephrology
    • Urology
    • Transplantation

    Background:

    • Live donor renal transplantation is a common procedure for end-stage renal disease.
    • Allograft calculi (stones) are a potential complication following renal transplantation.
    • Understanding risk factors and effective management is crucial for long-term graft survival.

    Observation:

    • Three patients developed calculi within their renal allografts post-transplantation.
    • Two patients presented with hypercalcemia and secondary hyperparathyroidism.
    • One patient had urinary stagnation and infection as contributing factors.

    Findings:

    • Subtotal parathyroidectomy effectively treated hypercalcemia and secondary hyperparathyroidism in two patients.
    • Ureteral reimplantation resolved urinary stagnation and infection in the third patient.
    • No further calculi developed in any patient after the interventions, and allograft function remained satisfactory.

    Implications:

    • Management of metabolic disturbances like hypercalcemia and secondary hyperparathyroidism is vital in renal transplant recipients.
    • Addressing urinary tract issues such as stagnation and infection is critical to prevent allograft calculi.
    • Timely and appropriate interventions can successfully manage allograft calculi, preserving long-term renal allograft function and patient outcomes.

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