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A short-TR single-echo spin-echo breath-hold method for assessing liver T2.

Marshall S Sussman1, Kartik S Jhaveri2

  • 1Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, 585 University Avenue, Room NUW-1-141D, Toronto, ON, M5G 2N2, Canada. marshall.sussman@utoronto.ca.

Magma (New York, N.Y.)
|December 10, 2023
PubMed
Summary

A new, fast spin-echo T2 mapping technique allows for breath-hold liver iron quantification. This method provides accurate T2 measurements, overcoming limitations of conventional longer scan times.

Keywords:
Iron OverloadLiverMagnetic Resonance ImagingSpin Echo Imaging

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Area of Science:

  • Magnetic Resonance Imaging
  • Medical Physics
  • Radiology

Background:

  • Conventional single-echo spin-echo T2 mapping for liver iron quantification requires long scan times, exceeding typical breath-hold durations.
  • This limitation hinders accurate assessment in clinical settings, particularly for patients with iron overload.

Purpose of the Study:

  • To investigate a novel, accelerated single-echo spin-echo T2 mapping technique suitable for breath-hold acquisition.
  • To evaluate the accuracy and reliability of this short TR (~100 ms) T2 mapping method for liver iron quantification.

Main Methods:

  • A short TR (~100 ms) single-echo spin-echo T2 mapping sequence was developed, acquiring each echo time (TE) image in ~17 seconds.
  • To mitigate T1 bias, the repetition time (TR) was incremented with each TE, maintaining a constant TR-TE interval.
  • Validation was performed using phantoms, 9 healthy volunteers, and 5 iron overload patients at 1.5T, comparing results against conventional methods and FerriScan.

Main Results:

  • In phantoms, the constant TR-TE technique yielded unbiased T2 estimates, unlike the conventional constant TR approach which underestimated T2.
  • Healthy volunteers showed no significant discrepancy between constant TR-TE T2 values and reference T2 values.
  • In iron overload patients, a high correlation (r² = 0.95) was observed between constant TR-TE T2 values and FerriScan, with a small discrepancy (0.6 ± 1.4 ms).

Conclusions:

  • The developed short-TR single-echo breath-hold spin-echo T2 mapping technique provides unbiased T2 estimates.
  • This accelerated method is accurate and reliable for liver iron quantification in both phantoms and clinical liver applications.