Small molecules as modulators of the proteostasis machinery: Implication in cardiovascular diseases

Area of Science:

• Cardiovascular Medicine
• Molecular Biology
• Proteostasis Network Research

Background:

• Cardiovascular diseases (CVDs) impose a significant socioeconomic burden globally.
• The proteostasis network is crucial for maintaining cardiac homeostasis and function.
• Impaired proteostasis is implicated in CVD development, including heart failure and atherosclerosis.

Purpose of the Study:

• To review the role of the proteostasis network in various cardiovascular diseases.
• To explore the therapeutic potential of small molecules targeting the proteostasis network for CVDs.

Main Methods:

• Literature review of studies on proteostasis and cardiovascular health.
• Analysis of research on small molecule modulators of the proteostasis network.
• Synthesis of evidence linking proteostasis disruptions to specific cardiovascular conditions.

Main Results:

• Proteostasis network components (chaperones, autophagy, UPS) are vital for cardiac health.
• Dysregulation of proteostasis contributes to protein dysfunction and toxicity in CVDs.
• Small molecules modulating proteostasis have demonstrated therapeutic effects in cardiovascular disease models.

Conclusions:

• The proteostasis network is a key player in cardiovascular homeostasis and disease pathogenesis.
• Targeting the proteostasis network with small molecules represents a promising therapeutic strategy for cardiovascular diseases.