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The causality between systemic inflammatory regulators and chronic respiratory diseases: A bidirectional
Guanyu Jiang1, Weici Liu1, Xiaokun Wang2
1Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, Jiangsu, China.
Cytokine
|December 10, 2023
Summary
This study used Mendelian randomization to identify 12 systemic inflammatory regulators linked to chronic respiratory diseases (CRDs). Findings offer new targets for CRD prevention and treatment.
Area of Science:
- Genetics and Immunology
- Respiratory Medicine
Background:
- Systemic inflammation is linked to chronic respiratory diseases (CRDs), but causal links are unclear.
- Identifying specific inflammatory regulators is crucial for understanding disease mechanisms.
Purpose of the Study:
- To investigate causative associations between systemic inflammatory regulators and five major CRDs using Mendelian randomization (MR).
- To identify specific inflammatory factors that influence the development or progression of CRDs.
Main Methods:
- Performed MR analyses on 41 serum cytokines using GWAS data from 8,293 individuals.
- Employed multiple MR methods including inverse variance weighted regression and MR-Egger regression.
- Conducted sensitivity analyses to assess pleiotropy and heterogeneity, including Cochrane's Q test and MR-PRESSO.
Main Results:
- Identified 12 genetically predicted systemic inflammatory regulators associated with CRDs.
- Specific factors like IL-1RA, IL-4, MIP-1A, PDGF-BB (risk) and IL-6 (protective) were linked to IPF.
- Other factors were identified as protective in COPD, asthma, bronchiectasis, and sarcoidosis, with robust sensitivity analyses.
Conclusions:
- Uncovered potential causal associations between systemic inflammatory modulators and common CRDs.
- Findings provide novel insights into inflammation-mediated CRD pathogenesis.
- Results suggest new avenues for CRD prevention and therapeutic strategies targeting inflammation.
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