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DLBCL arising from indolent lymphomas: How are they different?
Erin M Parry1, Sandrine Roulland2, Jessica Okosun3
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; Harvard Medical School, Boston, MA; Broad Institute of MIT and Harvard, Cambridge, MA.
Seminars in Hematology
|December 10, 2023
Summary
Transformation to diffuse large B-cell lymphoma (DLBCL) is an unpredictable event in indolent lymphomas. This review covers the clinical and biological aspects of transformed lymphomas, highlighting genetic basis and outcomes.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Transformation to diffuse large B-cell lymphoma (DLBCL) represents a critical, yet unpredictable, clinical event in the progression of indolent lymphomas.
- Retrospective studies reveal significant variability in transformation incidence among indolent lymphoma subtypes and associated adverse outcomes.
Approach:
- This review synthesizes current knowledge on transformed lymphomas by examining evolving technologies and unique tissue collections.
- It focuses on dissecting the genetic underpinnings, relationship to preceding indolent lymphomas, and comparative biology with de novo DLBCL.
Key Points:
- Understanding the genetic basis of transformed indolent lymphomas is crucial.
- Comparing the biology of transformed lymphomas with de novo DLBCL provides insights into distinct pathways.
- Variability in transformation incidence underscores the need for personalized risk assessment.
Conclusions:
- Current understanding of transformed lymphomas is advancing, particularly regarding their genetic landscape.
- Further research is needed to address outstanding questions in both clinical and biological domains.
- This review consolidates existing knowledge and identifies future research directions for transformed lymphomas.
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