Related Experiment Video
Updated: Jul 8, 2025
Author Spotlight: Development of Homogeneous κ-Carrageenan Sub-Microgel Baths for High-Resolution 3D Bioprinting
Published on: May 3, 2024
A 3D-Printed Cuttlefish Bone Elastomeric Sponge Rapidly Controlling Noncompressible Hemorrhage.
Xinchi Zhang1, Xuqiao Wang2, Pingping Yuan2
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Centre for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
A novel 3D-printed cuttlefish bone elastomeric sponge (CBES) demonstrates superior hemostatic performance. This innovative material enhances blood absorption and promotes tissue healing, offering a promising advancement for treating noncompressible hemorrhage.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Hemostasis
Background:
- Developing effective hemostatic agents for noncompressible hemorrhage is critical.
- Existing materials often lack sufficient blood absorption and rapid shape recovery.
- Cuttlefish bone has potential biomimetic and hemostatic properties.
Purpose of the Study:
- To fabricate and evaluate a 3D-printed cuttlefish bone elastomeric sponge (CBES) for enhanced hemostasis.
- To investigate the hemostatic mechanisms and tissue regeneration potential of CBES.
- To compare CBES performance against commercial gelatin sponges.
Main Methods:
- Fabrication of a 3D-printed elastomeric sponge incorporating cuttlefish bone powder (CBp).
- Characterization of the sponge's structure, mechanical properties, and shape memory.
- In vivo evaluation of hemostatic efficacy and tissue response compared to gelatin sponges.
Main Results:
- CBES exhibited ordered channels and porous structures with tunable mechanical strength and shape memory.
- CBp incorporation concentrated blood components, promoting red blood cell and platelet aggregation and activation.
- CBES demonstrated enhanced in vivo hemostatic performance and superior histiocytic infiltration and neovascularization compared to gelatin sponges.
Conclusions:
- CBp-loaded 3D-printed elastomeric sponges offer potent hemostatic capabilities.
- CBES promotes coagulation and guides tissue healing, showing potential in regenerative medicine.
- This approach broadens the hemostatic applications of traditional Chinese medicine components.
