Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental cholelithiasis in the ground squirrel.

B R MacPherson, R S Pemsingh, G W Scott

    Laboratory Investigation; a Journal of Technical Methods and Pathology
    |February 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Morphological features of sessile and circulating hemocytes in the cephalon of Gammarus setosus dementieva (Crustacea: Amphipoda) by light and electron microscopy.

    Journal of morphology·2018
    Same author

    QUININE PROPHYLAXIS IN MALARIA.

    British medical journal·2010
    Same author

    EPIDEMIC PNEUMONIC INFLUENZA AS SEEN IN MALAYA.

    British medical journal·2010
    Same author

    Piezoelectrically tuned short-cavity dye-laser design.

    Applied optics·2010
    Same author

    Prolonged labor, with special reference to postpartum hemorrhage.

    Journal of the American Medical Association·2010
    Same author

    Contacted mode-locking-dye cell.

    Applied optics·2010
    Same journal

    Changes in Three-Dimensional Intrahepatic Biliary Structures in Patients With Hepatobiliary Diseases Visualized Using Tissue-Clearing Methods.

    Laboratory investigation; a journal of technical methods and pathology·2026
    Same journal

    Genome-wide SNP-based Profiling of Loss of Heterozygosity Reveals Distinct Molecular Subgroup-specific Patterns in Gastrointestinal Stromal Tumors (GIST).

    Laboratory investigation; a journal of technical methods and pathology·2026
    Same journal

    AI-Assisted HER2 Scoring in Breast Cancer: Diagnostic Agreement and Understanding Discordance.

    Laboratory investigation; a journal of technical methods and pathology·2026
    Same journal

    Corrigendum to "POU2F3 in Small Cell Lung Cancer (SCLC): Diagnostic Utility in Neuroendocrine-Low/Negative SCLC and Discrimination From Other Thoracic Malignancies and Other Small Blue Round Cell Tumors" [Laboratory Investigation 2026;106(6):106124].

    Laboratory investigation; a journal of technical methods and pathology·2026
    Same journal

    Assessing the Effects of a 3D Pathology Tissue-Processing Workflow on Downstream Molecular Analyses.

    Laboratory investigation; a journal of technical methods and pathology·2026
    Same journal

    Transcription Factor Ets-1 is a Central Regulator of Redox Balance and Liver Regeneration Through EGF and TGF-β1 Signaling.

    Laboratory investigation; a journal of technical methods and pathology·2026
    See all related articles

    Richardson's ground squirrels fed a cholesterol-enriched diet developed gallstones. Increased mucus secretion and crystal aggregation were key factors in stone formation, mimicking human cholesterol cholelithiasis.

    Area of Science:

    • Gastroenterology and Hepatology
    • Animal Models in Disease Research
    • Biochemistry of Lipid Metabolism

    Background:

    • Gallstones, particularly cholesterol gallstones, are a common human ailment.
    • Understanding the mechanisms of gallstone formation is crucial for developing effective treatments.
    • Animal models are essential for studying complex physiological processes like cholelithiasis.

    Purpose of the Study:

    • To investigate the process of cholesterol gallstone formation in Richardson's ground squirrels.
    • To characterize the role of mucus secretion and crystal aggregation in gallstone development.
    • To evaluate the suitability of the ground squirrel as an animal model for cholesterol cholelithiasis.

    Main Methods:

    • Administration of a cholesterol-enriched diet to Richardson's ground squirrels for up to 20 weeks.

    Related Experiment Videos

  • Biochemical analysis of bile to determine lithogenic index.
  • Microscopic examination (light and scanning electron microscopy) of gallbladder contents and tissue.
  • Observation of crystal precipitation, growth, and aggregation.

    • Main Results:

    • Cholesterol-enriched diet induced gallstone formation in ground squirrels.
    • Increased mucus secretion preceded cholesterol crystal precipitation.
    • Crystals aggregated into microliths and then larger, mulberry-shaped stones.
    • Gallstone formation pattern closely resembled that observed in humans.

    Conclusions:

    • Richardson's ground squirrel is a suitable animal model for studying cholesterol cholelithiasis.
    • Epithelial cell involvement and mucus hypersecretion are critical in gallstone pathogenesis.
    • Further research using this model can elucidate the epithelial cell's role in gallstone formation.