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Comorbidity in the aging population with multiple sclerosis: a Danish nationwide study
Rolf Pringler Holm1, Malthe Faurschou Wandall-Holm1, Finn Sellebjerg2
1Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark.
Frontiers in Neurology
|December 11, 2023
Summary
Elderly individuals with multiple sclerosis (MS) have more acute and chronic comorbidities, increasing mortality risk. Managing these comorbidities is crucial for effective MS treatment strategies.
Area of Science:
- Neurology
- Geriatrics
- Epidemiology
Background:
- Multiple sclerosis (MS) is a progressive neurodegenerative disease.
- Aging populations with MS face increased risks of comorbidities.
- The impact of comorbidities on MS progression and outcomes requires further investigation.
Purpose of the Study:
- To assess acute and chronic comorbidities in elderly MS patients compared to matched controls.
- To investigate the influence of chronic comorbidities on all-cause mortality in MS.
Main Methods:
- Nationwide register-based study using the Danish Multiple Sclerosis Registry.
- Matched cohort design comparing MS patients (n=8,688) to general population controls (n=86,880).
- Charlson Comorbidity Index for chronic conditions; ICD-10 codes for acute conditions; Cox regression for mortality analysis.
Main Results:
- MS patients showed higher rates of acute hospitalizations (OR: 2.1) and longer hospital stays.
- A significantly greater burden of chronic comorbidities was observed in MS patients (p < 0.001).
- Chronic comorbidities (Charlson score ≥4) attenuated the increased mortality risk in MS patients.
Conclusions:
- Elderly individuals with MS have a higher prevalence of both acute and chronic comorbidities.
- Chronic comorbidities significantly increase the risk of all-cause mortality in MS patients.
- Comorbidity assessment is vital for optimizing treatment and management strategies in multiple sclerosis.
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