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Depression and sarcopenia-related traits: A Mendelian randomization study
Ding-Kun Wang1, Yi-Hao Li1, Xiao-Ming Guo2
1Department of Neurosurgery, Tongde Hospital of Zhejiang Province, Hangzhou 310016, Zhejiang Province, China.
World Journal of Psychiatry
|December 11, 2023
Summary
This study found depression causally linked to reduced muscle mass. Lower muscle strength may also increase depression risk, suggesting a bidirectional relationship between these conditions.
Area of Science:
- Genetics
- Epidemiology
- Gerontology
Background:
- Observational studies suggest a link between depression and sarcopenia.
- The causal nature of this association requires further investigation.
Purpose of the Study:
- To investigate the bidirectional causal relationship between depression and sarcopenia using Mendelian randomization.
Main Methods:
- Mendelian randomization analysis utilizing summary-level data from large genome-wide association studies.
- Instrumental variables for depression, appendicular lean mass (ALM), and hand grip strength were employed.
Main Results:
- Depression was causally associated with decreased appendicular lean mass (OR: 0.932, P = 0.005).
- Hand grip strength showed an inverse association with depression risk (OR: 0.200, P < 0.001).
- Sensitivity analyses confirmed these findings.
Conclusions:
- Depression is causally linked to reduced muscle mass.
- Decreased muscle strength may contribute to an increased risk of depression.
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