Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

86
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
86
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

229
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
229
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

227
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
227
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

176
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
176
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

179
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
179
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

213
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
213

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diabetes and socioeconomic status as key risk factors for colorectal cancer in the pashtun population: a case-control study.

BMC gastroenterology·2026
Same author

Cultural and ethnopharmacological uses of wildlife in the himalayan region of Azad Jammu and Kashmir, Pakistan.

Journal of ethnobiology and ethnomedicine·2026
Same author

Ruptured Vertebral-Anterior Spinal Artery Junction Aneurysm Presenting With Diffuse Subarachnoid Hemorrhage: Diagnostic Limitations of CT Angiography (CTA) and the Role of Digital Subtraction Angiography (DSA) in Management-Related Decision-Making.

Cureus·2026
Same author

CryptoShield-multilayered cryptographic framework for enhanced security and robust communication systems.

Scientific reports·2025
Same author

Antioxidant and renal protective effects of Nano-selenium on adenine-induced acute renal failure in canines.

Ecotoxicology and environmental safety·2024
Same author

Microbial-inoculated biochar for remediation of salt and heavy metal contaminated soils.

The Science of the total environment·2024

Related Experiment Video

Updated: Jul 8, 2025

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

413

Oro-Anal Transit Time and Colon Manometry: Predictability and Outcomes in Children With Functional Constipation.

Muhammad Shaukat1, Muhammad Altaf2

  • 1Pediatric Gastroenterology, Freeman Health Center, Joplin, USA.

Cureus
|December 11, 2023
PubMed
Summary

Oropharyngeal-anal transit time (OTT) did not correlate with colonic manometry (CM) findings in children with chronic idiopathic constipation (CIC). Colonic manometry guided treatment changes effectively, improving symptoms in most children with refractory constipation.

Keywords:
acecolonic manometryconstipationoro-anal transit timesitzmarks

More Related Videos

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
09:44

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Published on: September 11, 2012

22.2K
Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
07:41

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

14.1K

Related Experiment Videos

Last Updated: Jul 8, 2025

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

413
Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
09:44

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Published on: September 11, 2012

22.2K
Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
07:41

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

14.1K

Area of Science:

  • Pediatric Gastroenterology
  • Colorectal Surgery
  • Motility Disorders

Background:

  • Chronic idiopathic constipation (CIC) is a common pediatric condition.
  • Accurate diagnostic tools are essential for guiding treatment strategies in pediatric CIC.
  • Oropharyngeal-anal transit time (OTT) and colonic manometry (CM) are used to assess colonic function.

Purpose of the Study:

  • To evaluate the correlation between OTT and CM in children with CIC.
  • To determine the clinical utility of OTT and CM in directing treatment for pediatric CIC.

Main Methods:

  • Retrospective chart review of 44 children diagnosed with CIC.
  • Evaluation of both OTT (SITZMARKS®) and CM.
  • Median follow-up of one year.

Main Results:

  • OTT results did not correlate with CM findings in children with CIC.
  • CM testing led to treatment change acceptance in approximately 90% of children.
  • Children with abnormal CM showed a trend towards greater symptom improvement compared to those with normal CM.

Conclusions:

  • OTT is not a reliable predictor of colonic dysmotility in children with CIC.
  • CM is a valuable tool for guiding therapeutic interventions in pediatric CIC.
  • Alternative treatments beyond stimulant laxatives should be considered for refractory constipation in children.