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Related Experiment Videos

Auranofin-associated colitis and eosinophilia.

C J Michet, J Rakela, H S Luthra

    Mayo Clinic Proceedings
    |February 1, 1987
    PubMed
    Summary

    Gold compounds like auranofin can cause gastrointestinal issues in rheumatoid arthritis patients. Prompt attention to bowel symptoms is crucial, as cromolyn sodium may offer relief for gold-induced colitis.

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    Area of Science:

    • Rheumatology
    • Gastroenterology
    • Pharmacology

    Background:

    • Gold compounds, including oral auranofin, are utilized for rheumatoid arthritis management.
    • Gastrointestinal disturbances are recognized potential side effects of gold therapy.

    Observation:

    • A 50-year-old woman with rheumatoid arthritis experienced persistent diarrhea, abdominal tenderness, nausea, and vomiting after auranofin treatment.
    • These symptoms continued even after discontinuing auranofin.

    Findings:

    • The patient was diagnosed with gold-induced colitis and eosinophilia.
    • Treatment with cromolyn sodium successfully alleviated the gastrointestinal symptoms.

    Implications:

    • This case highlights a rare but significant gastrointestinal complication associated with auranofin.
    • Clinicians should be vigilant for evolving bowel symptoms in patients undergoing auranofin therapy.

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