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Comparing Prophylactic Effect of Levetiracetam, Sodium Valproate, and Propranolol in Pediatric Migraine: A Randomized
Afshin Fayyazi1, Nasrollah Pezeshki2, Hosein Mansuri3
1Department of Pediatric Neurology, Hamadan University of Medical Sciences, Hamadan, Iran.
Insights
Levetiracetam shows promise in reducing migraine severity and frequency in children. This study suggests it may be a viable option for pediatric migraine prophylaxis, though further research is needed.
Area of Science:
- Pediatric Neurology
- Clinical Pharmacology
Background:
- Migraine prevalence is increasing in children.
- Current migraine treatment includes acute and prophylactic therapies.
- Anti-epileptic drugs like Levetiracetam are being explored for migraine treatment.
Purpose of the Study:
- To compare the efficacy of Levetiracetam, Sodium Valproate, and Propranolol for migraine prevention in children.
- To evaluate the impact of these treatments on headache score, PedMIDAS, and headache frequency.
Main Methods:
- A randomized clinical trial involving 39 children with migraine.
- Children were divided into three groups receiving Levetiracetam, Sodium Valproate, or Propranolol.
- Assessment included headache scores, PedMIDAS, and headache frequency pre- and post-intervention.
Main Results:
- Levetiracetam significantly reduced headache severity (P=0.026), frequency (P=0.024), and PedMIDAS scores (P=0.001).
- Pain relief percentages were 69.24% for Propranolol, 92.31% for Sodium Valproate, and 30.76% for Levetiracetam.
- No significant differences were observed between the three treatment groups overall.
Conclusions:
- Levetiracetam demonstrates potential as a prophylactic agent for pediatric migraines.
- Further investigation into its role in migraine management for children is warranted.
Objectives:
Epidemiologic studies point to an increased prevalence of migraine in children in recent decades. Migraine treatment involves acute and prophylactic therapy. Recently, such anti-epileptic drugs as Levetiracetam have been used to treat adult migraines. The present study aimed to compare the efficacy of Levetiracetam, Sodium Valproate, and Propranolol in preventing migraine headaches in children.
Materials & Methods:
In this clinical trial, children with migraine were randomly divided into three groups. Each group consisted of 13 children. Two groups were treated with Propranolol and Sodium Valproate, respectively. Another group (the case) was treated with Levetiracetam. The patients were assessed based on headache score, PedMIDAS, and headache frequency before and three months after the intervention. Finally, the data was analyzed using descriptive and analytical statistical methods.
Results:
Levetiracetam significantly reduced the headache severity (P=0.026), frequency (P=0.024), and PedMIDAS score (P=0.001) in children with migraine. However, no significant difference was found between the three groups. The percentage of patients who experienced pain relief was detected as 69.24%, 92.31%, and 30.76% in the Propranolol, Sodium Valproate, and Levetiracetam groups, respectively.
Conclusion:
This study concluded that Levetiracetam can be used as a migraine prophylaxis drug in children.
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