Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
Rapid Identification of Pathogens01:25

Rapid Identification of Pathogens

MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...
Automated Microbial Diagnostics01:24

Automated Microbial Diagnostics

Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multicolor Amplification-Free RNA Detection with Cas13a and Cas13b.

Analytical chemistry·2026
Same author

Direct Single-Molecule Detection of mRNA-LNP Drugs in Blood.

Analytical chemistry·2025
Same author

Digital SERS bioanalysis of single-enzyme biomarkers.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Purification/Amplification-Free RNA Detection Platform for Rapid and Multiplex Diagnosis of Plant Viral Infections.

Analytical chemistry·2023
Same author

Development of fluorogenic substrates for colorectal tumor-related neuropeptidases for activity-based diagnosis.

Chemical science·2023
Same author

Compact wide-field femtoliter-chamber imaging system for high-speed and accurate digital bioanalysis.

Lab on a chip·2022
Same journal

Parallelized contactless microfluidic dispenser with superhydrophobic nozzles for scalable combinatorial screening.

Biomicrofluidics·2026
Same journal

Time resolved luminescence of millisecond lifetime dyes in droplet microfluidic systems.

Biomicrofluidics·2026
Same journal

Emerging trends in functional molecularly imprinted polymers for electrochemical detection of biomarkers.

Biomicrofluidics·2025
Same journal

Deep learning assisted mechanotyping of individual cells through repeated deformations and relaxations in undulating channels.

Biomicrofluidics·2025
Same journal

<i>Giardia</i> purification from fecal samples using rigid spiral inertial microfluidics.

Biomicrofluidics·2025
Same journal

Point of care sepsis diagnosis: Exploring microfluidic techniques for sample preparation, biomarker isolation, and detection.

Biomicrofluidics·2025
See all related articles

Related Experiment Video

Updated: Jun 8, 2026

A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments
12:21

A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments

Published on: August 6, 2013

10.6K

Toward versatile digital bioanalysis.

Jun Ando1, Rikiya Watanabe1

  • 1Cluster for Pioneering Research, RIKEN, Wako 351-0198, Japan.

Biomicrofluidics
|December 11, 2023
PubMed
Summary
This summary is machine-generated.

Digital bioanalysis offers sensitive single-molecule detection for disease diagnostics. Overcoming cost and equipment barriers is key to unlocking its full potential in versatile biomedical applications.

More Related Videos

Simple Bulk Readout of Digital Nucleic Acid Quantification Assays
06:55

Simple Bulk Readout of Digital Nucleic Acid Quantification Assays

Published on: September 24, 2015

8.3K
Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging
04:33

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Published on: December 8, 2023

899

Related Experiment Videos

Last Updated: Jun 8, 2026

A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments
12:21

A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments

Published on: August 6, 2013

10.6K
Simple Bulk Readout of Digital Nucleic Acid Quantification Assays
06:55

Simple Bulk Readout of Digital Nucleic Acid Quantification Assays

Published on: September 24, 2015

8.3K
Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging
04:33

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Published on: December 8, 2023

899

Area of Science:

  • Biophysics
  • Biotechnology
  • Medical Diagnostics

Background:

  • Digital bioanalysis focuses on sensitive, rapid single-molecule detection of biomolecules.
  • Rooted in single-molecule biophysics, it provides deep insights into biomolecular mechanisms.
  • This technique holds promise for early disease diagnosis and monitoring via biomarker detection.

Purpose of the Study:

  • To identify essential requirements for versatile digital bioanalysis.
  • To explore prospects for biomedical applications enabled by enhanced versatility.

Main Methods:

  • The study is based on principles of single-molecule biophysics.
  • It analyzes the limitations hindering widespread adoption of digital bioanalysis.
  • The focus is on identifying requirements for improved versatility.

Main Results:

  • High cost and specialized equipment for microdevice fabrication limit accessibility.
  • Lack of versatility is a significant barrier to the widespread adoption of digital bioanalysis.
  • Attaining versatility is crucial for unlocking broader biomedical applications.

Conclusions:

  • Digital bioanalysis offers unparalleled sensitivity and precision for biomolecular studies.
  • Addressing cost and equipment challenges is vital for broader accessibility.
  • Versatile digital bioanalysis platforms will significantly advance disease diagnostics and monitoring.